Fig. 7
From: L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Substrate occlusion in inward-facing SLC7 transporters. a Comparison of the structures of BasC (rainbow) bound to 2-AIB (orange) (PDB ID: 6F2W) in non-occluded state and GkApcT (salmon) bound to l-alanine (cyan) (PDB ID: 5OQT) in occluded state. Tilting of TM1a and TM6b, together with the accompanying TM7, closes the substrate vestibule to occlude the substrate at the cytoplasmic side (arrows). Concomitantly, TM1a interacts and attracts TM5 in the occlusion state (arrow). Only TM1, TM3, TM5, TM6, TM7, and TM8 are depicted for clarity. b Detail of the interactions of K154 in BasC (gray dashed line) and K191 in GkApcT (salmon dashed lines) in the structures shown in a
