Fig. 3

Enantioselective coupling of N-tosyl isatins with toluene and its derivatives. Reaction conditions: 1 (0.1 mmol), toluene or its derivatives (5.0 mmol), PhCl (4.0 mL), 25 °C. The data in parentheses were obtained under neat conditions [1 (0.1 mmol), toluene or its derivatives (4.0 mL), 25 °C]. Yields were determined from the material isolated after chromatographic purification. Enantiomeric excesses were determined by HPLC analysis on a chiral stationary phase. ^aOn a 1.0 mmol scale, 72 h, yield of 2e = 69%, ee of 2e = 98%