Fig. 8
PBC-relevant and AIH-relevant pMHCII-NPs blunt PBC, PSC, and AIH in a disease non-specific manner. a Percentage of tetramer+CD4+ T-cells in NOD.Abcb4–/– mice in response to Cys-NP, PDC166–181/IAg7-NP, or CYPD398–412/IAg7-NP therapy [2 doses/week for 5 weeks starting at 6 weeks of age; n = 9–11 (bottom), or 6–7 (top), respectively, from 2 to 3 experiments]. b Average PSC scores (top) and representative H&E-stained or Picrosirius-Red-stained liver sections (bottom) from the mice in a (n = 9, 9 and 7 mice/NP type, respectively; 2–3 experiments). Scale bars: 100 μm. c Serum TBA and ALT levels in the mice in a (n = 11, 8 and 7 mice/NP type, respectively; 2–3 experiments). d Percentage of tetramer+ cells in NOD mice infected with Ad-hFTCD and treated with CYPD398–412/IAg7-NPs (n from top, middle, and bottom panels = 5, 5, and 5, respectively), FTCD58–72/IAg7-NPs (n = 9, 4, 4, respectively) or PDC166–181/IAg7-NPs (n = 4, 4, 10, respectively) or left untreated (n = 7, 6, 9, respectively). e Serum ALT levels in the mice in d [n = 11, 5, 9, and 10 mice (left to right); 2–3 experiments]. f AIH histopathological scores (top) and representative H&E-stained and Picrosirius-Red-stained liver sections (bottom) for the mice in e. Scale bars: 100 μm. Data correspond to the mean ± SEM. P values were calculated via Mann–Whitney U
