Fig. 9 | Nature Communications

Fig. 9

From: Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

Fig. 9

AIH-relevant pMHCII-NPs are as efficient as PBC-relevant pMHCII-NPs to blunt PBC in NOD.c3c4 mice. a Percentage of tetramer+ cells in untreated/Cys-NP-treated (n = 7), or CYPD398–412/IAg7-NP-treated mice (n = 5). b and c Average microscopic (b) or macroscopic (c) liver scores for the mice treated with PDC166–181/IAg7-NPs or PDC82–96/IAg7-NPs (n = 23, five experiments for b and n = 27, six experiments for c) vs. CYPD398–412/IAg7-NPs (n = 5, one experiment), as compared to untreated/Cys-NP-treated mice (n = 20, six experiments for b and n = 30, seven experiments for c). Data correspond to the mean ± SEM. P values were calculated via Mann–Whitney U

Back to article page