Fig. 1 | Nature Communications

Fig. 1

From: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

Fig. 1

DNA methylation and gene expression in HPVOPSCC and normal oropharynx. Scatter plots (left panels) separated by gene expression quartiles based on the expression levels in either tumor or normal samples (n = 3290, 3289, 3289, 3290 for Q1, Q2, Q3, Q4, respectively; Q4 is the highest expression) showing methylation ratio at 100 bp segments including genomic loci within (a) and outside (b) CpG islands in genes with promoter-associated CpG islands (CGI genes, n = 13158). CGI genes have the CpG island-containing promoter by definition, though they may have additional CpG island(s) outside of the promoter region. a Shows methylation status at each 100 bp segment with such CpG island. As CGI genes also have various methylation profiles at CpG sites outside of the island(s), i.e. shore(s) etc., such 100 bp segments are plotted in b. Thus non-overlapping 100 bp segments of an identical set of CGI genes are shown in a, b. Right panels show the mean values. TSS transcription start site

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