Fig. 1
From: Impaired cortico-striatal excitatory transmission triggers epilepsy
Ethosuximide-sensitive SWDs predominantly appear in the SSC, mPFC and CPu of Stxbp1+/− mice. a SSC SWDs in Stxbp1+/− mice. (Left) Bilateral ECoG and electromyogram (EMG) recordings in an Stxbp1+/− mouse. (Right) Number of SWDs (24 h recordings). WT (N = 6) and Stxbp1+/− mice (N = 6) (Mann–Whitney U test; **P = 0.0047). b Ethosuximide efficiently suppressed SWDs. (Left) Representative recordings. (Right) Number of SWDs (2.5 h recordings). Stxbp1+/− mice (N = 6) (Mann–Whitney U test; vehicle vs. ethosuximide, **P = 0.005). c, SWDs predominantly appeared in the SSC, mPFC, and CPu of Stxbp1+/− mice. (Left) Simultaneously recorded SWDs in multiple brain regions. (Right) Number of SWDs during the light period (3-hours recording). WT (N = 5) and Stxbp1+/− (N = 5) mice. Statistical comparisons between WT and Stxbp1+/− mice were made in each brain region (Mann–Whitney U test, WT vs. Stxbp1+/−, SSC: *P = 0.0117; mPFC: *P = 0.0112; CPu: **P = 0.0079; Amg: *P = 0.0117; Thal: *P = 0.0112; CA1: *P = 0.0112). Data represent mean ± SEM. *P < 0.05, **P < 0.01. Mouse numbers in parentheses. mPFC medial prefrontal cortex, CPu caudate putamen, Amg basolateral amygdala, Thal ventroposterior thalamus (a part of somatosensory system), CA1 hippocampus CA1 region, VC visual cortex
