Fig. 7
From: Impaired cortico-striatal excitatory transmission triggers epilepsy
Temporal down-regulation of striatal FSIs at SWD onset in Stxbp1+/− mice. a Averaged spike waveforms of single units from a pFSI and a pMSN (FSI, 52,478 spikes; MSN 1,369 spikes). b Representative single unit activities of one pFSI and two pMSNs (raster plot, top), simultaneously recorded SSC-ECoG, EMG, and CPu LFP around the onset of cortical SWD (arrow). c Averaged peri-event time histograms (500 ms bins) of pFSI (18 cells) and pMSNs (95 cells) from 10 Stxbp1+/− mice. The timings of the SWD onset were aligned at 0 s. d pFSIs activity at the onset of SWDs (−0.5 to + 0.5 s) significantly decreased compared to baseline (−5 to −4 s), while pMSNs did not. pFSIs: baseline vs. onset, Mann–Whitney U test, *P = 0.0279, pMSNs: P = 0.5831. Mean ± SEM. *P < 0.05
