Table 1 Candidate genes with eQTLs to T2D enhancer variants

From: Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

Locus

# Candidate genes

Enhancer varianta

eQTL genes

eQTL P-valueb

Shared eQTLc

10p13

3

rs11257655

CAMK1D

1.72E-14

Y

8p11

2

rs508419

NKX6-3

5.59E-10

Y

12q24

13

rs1260294

ABCB9

2.63E-07

Y

3q27

1

rs7646518

IGF2BP2

7.49E-07

Y

2q21

3

rs4954179

ACMSD

5.43E-06

Y

2q21

3

rs4954179

TMEM163

9.69E-05

Y

15q22

6

rs17205526

C2CD4B

0.00088

Y

4q35

1

rs116401167

ACSL1

0.04

Y

5q13

1

rs7732130

PDE8B

0.048

Y

  1. aEnhancer variant with highest PPA per signal listed
  2. badjusted eQTL P < 0.05; P-values reported are uncorrected
  3. cBayesian co-localization probability of shared signals is greater than probability of distinct signals
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