Table 4 Human SNP heritability (h2SNP) of meningitis in the MeninGene cohort

From: Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Phenotype

Method

Heritability

Error

p-value

Susceptibility (pneumococcal)

GCTA

0.25

0.05

2.4 × 10–6

LDAK

0.29

0.07

3.9 × 10–6

Severity (any species)

GCTA

0.29

0.11

2.8 × 10–5

LDAK

0.49

0.14

1.4 × 10–4

  1. Heritability for susceptibility and severity of meningitis in Dutch adults. Heritabilities are shown on the liability scale (adjusted for population prevalence and case ascertainment ratio). We used two methods for each phenotype, GCTA and LDAK. The latter corrects for linkage disequilibrium when estimating the kinship between genotypes. All results showed significant (p < 0.05) evidence for a heritability above zero
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