Fig. 4 | Nature Communications

Fig. 4

From: Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

Fig. 4

Proposed mechanistic features of FXN activation on NFS1 and ISCU. Schematic of the NFS1 Cys-loop trajectory, mediated by FXN-induced conformational changes on ISCU in the LPPVK region. Subunits of NFS1, ISCU and FXN are colored violet, cyan and orange respectively. Key residues discussed in the text are shown as sticks. The Cys-loop from NFS1 is shown as coil, and the LPPVK region Inset shows the orientation of complex from which the cartoon representation is derived

Back to article page