Fig. 3

SNF5 causes changes in chromatin state that are independent of its impact on MYC. a Scatterplots showing log₂-fold changes in ATAC-Seq peaks for OmoMYC and SNF5, compared to EGFP samples. b Differential ATAC-Seq peaks were separated based on whether they are TSS-proximal (≤1 kb upstream or 100 bp downstream of the TSS) or TSS-distal (greater than these parameters). c Graph presents a breakdown of the 2491 ATAC-Seq peaks induced by SNF5, according to their distance from the nearest annotated TSS. d GO analysis of genes associated with ATAC-seq peaks induced by SNF5 expression. e De novo motif analysis of ATAC-seq peaks induced by SNF5 expression, showing the top four motifs identified. f Scatterplot showing the log₂-fold changes of MYC ChIP-Seq read counts (SNF5/EGFP) on the x-axis and the log₂-fold changes of ATAC-Seq read counts (SNF5/EGFP) on the y-axis at all promoters