Table 1 Median-effect doses (IC50) of Delta-24-RGD in pHGG and DIPG cell lines

From: The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

 

Cell lines

IC50 (MOIs ± SD)

pHGG

CHLA-03-AA

10.22 ± 3.1

 

PBT-24

0.8 ± 0.06

 

SF188

9.6 ± 0.5

 

SJ-GBM2

32 ± 7.1

 

CHLA-200

5 ± 0.06

DIPG

TP54

9.6 ± 3.1

 

DIPG IV

3.6 ± 1.8

 

TP80

39.7 ± 10.9

 

TP83

51.9 ± 13.7

 

TP84

68 ± 4.1

 

JHH-DIPG1

26.2 ± 1.5

 

JHH-DIPG16A

9.6 ± 5.9

  1. The IC50 value (MOIs) is the median-effect dose (dose affecting 50% of the cells, i.e., 50% survival). IC50 = 50% inhibitory concentration; MOI=multiplicity of infection
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