Fig. 5
From: Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
Human breast tumors exhibit high-levels of Pol I expression. a IHC staining of Pol I in normal human breast tissue and invasive breast tumor tissue. b IHC staining of Pol I in TNBC and ERα+ tumors. Pol I intensity scoring TNBC compared to ERα+ tumors, t-test, P < 0.01. Error bars ± SD. Asterisk denotes significance. Scale bar = 240 µm. c Survival curve showing induced expression of Pol I and UBF correlates with lower relapse-free survival in patients with breast cancer, P < 0.006. d Schematic model showing TGFβ-induced, G1/S arrest of the cell cycle during EMT, accompanied by association of Snail1, Pol I and UBF with rDNA operons, TIP5 dissociation, and the generation of new Rictor-associated ribosomes. e Model depicting reduced primary tumor growth and metastasis via CX-5461-mediated inhibition of rRNA synthesis
