Fig. 1
Genetic and phenotypic data of 1452 isolates. a MIC distributions for four drugs. Dotted red line represents the WHO recommended critical concentration on 7H10 media; blue line represents the lower limit of achievable serum concentration from pharmacodynamic studies (Supplementary Table 2). b Allele frequency distribution relative to H37Rv. The isolate count axis interrupted and scaled to accommodate the data range. c Heatmap displaying genome-level similarity of the isolates. Similarity assessed as isolate–isolate genetic co-variance. Isolates indexed in lineage order L1, L2, L3, L4 (4., 4.1, 4.3), and L5 as shown. Co-variance ruler displayed on the far right with darker red indicating higher similarity/co-variance. Phylogenetic tree of the same isolates is given in Supplementary Fig. 4. Figure 1a–c can be regenerated using code in Supplementary Data 8 that will refer to data items provided in the Source Data file (compressed source data folder)
