Table 2 PVE for each drug attributable to subsets of genetic variations

From: GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

Drug

All PVE

All SE

woDR PVE

woDR SE

woDRwoNC PVE

woDRwoNC SE

DR-related PVE

NC-related PVE

INH

0.809

0.020

0.732

0.032

0.723

0.029

0.08

0.01

RIF

0.838

0.017

0.701

0.034

0.692

0.033

0.14

0.01

RFB

0.833

0.023

0.722

0.041

0.693

0.042

0.11

0.03

EMB

0.748

0.027

0.674

0.036

0.665

0.035

0.07

0.01

PZA

0.659

0.038

0.634

0.044

0.602

0.043

0.03

0.03

KAN

0.833

0.022

0.671

0.040

0.658

0.041

0.16

0.01

AMI

0.879

0.019

0.639

0.057

0.640

0.055

0.24

<0.01

CAP

0.743

0.030

0.690

0.038

0.666

0.038

0.05

0.02

ETA

0.701

0.034

0.689

0.038

0.675

0.038

0.01

0.01

STR

0.710

0.033

0.604

0.047

0.601

0.045

0.11

<0.01

MXF

0.643

0.058

0.494

0.083

0.456

0.081

0.15

0.04

  1. PVE all measurable genetic variation given along with PVE related to variation excluding known drug resistance regions and non-canonical regions associated in this study (n = 1452 isolates). Drug abbreviations detailed in Supplementary Table 2. PVE: proportion of variance explained. DR: drug resistance regions as detailed in the methods. NC: Non-canonical regions specified in Table 1. wo: without. SE: standard error
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