Table 1 Pathways distinguishing the HER2+ MET-like and HER2− EMT-like CTCs. The p-value was determined by Fisher’s Exact Test
Top-ranked pathways | p-value | Roles |
|---|---|---|
Integrin-linked kinase signaling | 2.17E-08 | EMT/MET |
Stabilization and expansion of the E-cadherin adherens junction | 3.66E-06 | EMT/MET |
Signaling events mediated by focal adhesion kinase | 1.21E-04 | EMT/MET |
Validated targets of C-MYC transcriptional activation | 1.38E-04 | CSC |
PDGFR-beta signaling pathway | 6.56E-04 | CSC |
AP-1 transcription factor network | 5.88E-04 | |
RhoA signaling pathway | 3.28E-04 | CSC |
Regulation of Telomerase | 1.73E-03 | CSC |
ErbB1 downstream signaling | 2.22E-03 | CSC |
PAR1-mediated thrombin signaling events | 1.16E-03 |
