Fig. 3 | Nature Communications

Fig. 3

From: Nanopore blockade sensors for ultrasensitive detection of proteins in complex biological samples

Fig. 3

Pathways for a 50 nm MNP entering into a 30 nm nanopore. Electric potential and field distribution, as well as the corresponding approximated ionic currents as a function of distance related to the nanopore on a 180-nm-thick SiN membrane are present. a Direct entry. MNP is located at a distance of (i) 255 nm, (ii) 205 nm, (iii) 155 nm, (iv) 105 nm, (v) 55 nm away from the trans-side nanopore orifice. White solid lines represent the electric field lines in the electrolyte region. Approximated ionic current as a function of distance of the MNP from the trans-side nanopore orifice. b Indirect entry. The MNP is located at a distance of (i) 120 nm, (ii) 100 nm, (iii) 80 nm, (iv) 60 nm away from centre axis of the cis-side nanopore orifice. Electric potential distribution is colour coded in Volt (0~100 mV). White solid lines represent the electric field lines in the electrolyte region. Approximated ionic current as a function of distance of MNP from the centre axis of the cis-side nanopore orifice

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