Fig. 6 | Nature Communications

Fig. 6

From: The structural basis of translational control by eIF2 phosphorylation

Fig. 6

Model for eIF2B GDP exchange and ternary complex (TC) formation. A series of steps for guanine nucleotide exchange factor (GEF) action and recruitment of initiator tRNA to form TC based on our structures and docking of the GEF domain (PDB 1PAQ), GDP (PDB 4RD6) or initiator tRNA (3JAP, chain 1), as outlined in the main text and Supplementary Movie 2. Grey arrows indicate steps affected by eIF2(αP)

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