Fig. 6 | Nature Communications

Fig. 6

From: Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique

Fig. 6

SNO analysis of SNAP-treated and non-treated (control) SH-SY5Y cells. a–b Top 20-enriched Gene Ontology (GO) terms (PANTHER Overrepresentation Test, http://www.pantherdb.org/, p values defined by Fisher’s exact test) of the SH-SY5Y SNO proteome: a molecular function and b biological process. c Volcano plot of SNO peptides in SNAP-treated vs non-treated samples. Green dots (n = 39) represent significantly downregulated (≥ 1.5-fold, ANOVA p value ≤ 0.05) and blue dots (n = 65) significantly upregulated (≥ 1.5-fold, ANOVA p value ≤ 0.05) SNO peptides. d High-confidence STRING network of proteins with significantly changed (≥ 1.5-fold, ANOVA p value ≤ 0.05) SNO levels. Proteins with upregulated SNO sites are marked blue, with downregulated green and with both up- and downregulated red. P values derived from n = 4 biological replicates. Source data are provided as a Source Data file

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