Fig. 7
From: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
Two models of SOCS2-substrate receptor recruitment. a Illustration of a “cis” recognition where the two binding sites on the same molecule of GHR, pY487 and pY595, fold into a hairpin structure for SOCS2 binding. SOCS2 is shown in white surface, the hairpin structure is illustrated by connecting the two peptides (yellow cartoon) with a red dashed line. b Illustration of a “trans” recognition where SOCS2 recruits two molecules of receptor tails (cyan and yellow dashed lines) simultaneously after dimerization of the receptor at the membrane
