Table 2 Comparison of detail analysis results between MUSIC and LRICA

From: Model-based understanding of single-cell CRISPR screening

Datasets

Technology

Demonstrated perturbation

Output

LRICA

MUSIC

Human K562 (3 UPR related genes, GSM2406677)

Perturb-seq4

ATF6, PERK, IRE1α

Overall perturbation effect

—

The three perturbations’ overall perturbation effect ranks 1st

   

Topic-specific functional perturbation effect

UPR

• UPR

• Apoptosis23

   

Perturbation relationship

The perturbation of PERK has a greater impact than those of ATF6 and IRE1α.

TPDS(PERK) = 94.0

TPDS(IRE1α) = 23.2

TPDS(ATF6) = 11.0

Human K562 (83 UPR related genes, GSM2406681)

Perturb-seq4

EIF2S1

Overall perturbation effect

—

Rank 1st

   

Topic-specific functional perturbation effect

UPR

UPR

   

Perturbation relationship

—

cor(EIF2S1, DHDDS) = 0.99

  1. cor(a,b) represents the Pearson correlation coefficient of topic distribution between perturbation a and perturbation b
  2. TPDS(a) represents the impact score to evaluate the overall perturbation effect of perturbation a
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