Fig. 6
Drug-tolerant cells exhibit changes in chromatin landscape and activating marks preferentially bind to rescue genes. a Heatmap representing abundances of differentially altered chromatin marks as identified by global chromatin profiling of sensitive and drug-tolerant D425 and D458 cells passaged in DMSO or BETi (JQ1 and IBET151) for 24 h. Red and blue respectively represent values above and below the median across each row. Source data: Supplementary Data File 8. b, c ChIP-seq binding scores (Z-transformed) of d H3K4me3 and e H3K27ac marks to rescue genes identified in ORF screens in sensitive cells treated with DMSO (n = 2) or 1 μM JQ1 (n = 2) and drug-tolerant cells passaged in 1 μM JQ1 (n = 4). Error bars depict mean ± SEM. Asterisks denote significant differences (*p < 0.05, **p < 0.01, ***p < 0.001) as determined by two-tailed unpaired t-tests. Source data: Source Data File
