Fig. 7 | Nature Communications

Fig. 7

From: SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis

Fig. 7

Sgf73p-mediated mRNP surveillance facilitates proteostasis. a Under physiological conditions, the proteasome-dependent separation of the Sgf73-DUBm from SAGA is required for surveillance of mRNP biogenesis. The physical interaction between Sgf73p and Yra1p facilitates proper chromatin recruitment and RNA binding of Yra1p. b During stress, Sgf73p accumulates in the UASs of specific genes, and Sgf73p retention initiates the Mex67p-mediated non-canonical mRNA export pathway to bypass quality control. Overall, Sgf73p regulates the plasticity of gene expression by interacting with key mRNA export factors to maintain proteostasis and maximize cell survival under environmental uncertainty

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