Fig. 5

acGM-1.8 suppress the growth of two tumor models in mice. a Schematic illustration of the treatment procedure of acGM-1.8 in two types of tumors, S180 sarcoma and B16 melanoma, growing in mice. When the tumor diameter reached 0.5 cm, the mice were randomly divided into four groups and treated with: i) PBS for 14 days; ii) acGM-1.8 (10 mg/kg) for 14 days; iii) acGM-1.8 (10 mg/kg) for 14 days and then PBS for 14 days; iv) acGM-1.8 for 28 days. PBS or acGM-1.8 was intratumorally injected every two days. b Survival ratio of the S180 sarcoma-bearing mice in the four groups. c Gross view of the S180 tumor samples. d Measurement of the S180 tumor size. e Measurement of the S180 tumor weight. f Survival ratio of the B16 melanoma-bearing mice in the four groups. g Gross view of the B16 tumor samples. h Measurement of the B16 melanoma tumor size. (i) Measurement of the B16 melanoma tumor weight; *P < 0.05 between the two compared groups; ns: no significance; n = 5