Fig. 6
From: Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Alternative splicing modulates aggregation propensity. a Cartoon schematic for tau 4R and 3R splice isoforms illustrate the difference in primary amino-acid sequence leading into the amyloidogenic 306VQIVYK311 motif. b A full combinatorial panel of R2R3-P301L and R1R3-P301L chimeras were aggregated in vitro. 306VQIVYK311 is shown in blue, amino acids common between the splice isoforms are shown in gray, amino acids unique to an R3 isoform are colored red, amino acids unique to an R4 isoform are colored green. The aggregation kinetics, represented as t1/2 in hours with 95% CI, are listed in the right-side column alongside its respective peptide
