Fig. 1
From: Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
DNA damage and senescent cell accumulate in radiation ulcer. a Representative images of hind limb 0–60 days post-radiation (top), representative histological analysis of rat skin tissues 0–60 days post-radiation (bottom). b Representative immunofluorescence pictures of γ-H2AX in rat skin tissues 0–60 days post-radiation. c Western blot analysis of γ-H2AX expression in rat skin tissues 0–60 days post-radiation. d Representative SA-β-gal staining in rat skin tissues 0–60 days post-radiation. e Western blot analysis of p16 and p21 levels in rat skin tissues 0–60 days post-radiation. f Representative images of radiated-hind limb after subcutaneously injected the senescent cells with an equal volume of growth factor-reduced Matrigel or control. This test was repeated three times. Representative images were shown. Bars represent 200 μm (bottom) (a), 100 μm (b), 200 μm (d)
