Fig. 4
From: Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
Cordycepin prevents DNA damage and cell senescence in vivo. a–c Representative immunofluorescence pictures and quantification of γ-H2AX in rat skin, mouse intestine and mouse tongue sections from normal animals and irradiated animals 35 days after irradiation, respectively. Basal progenitor marker cytokeratin 14 (K14) was used to label the basal progenitor layer of tongue. The γ-H2AX positive nuclei was calculated using Image J software. d Representative SA-β-gal staining in skin tissues from normal rats and irradiated rats 35 days after radiation. ML385: NRF2 inhibitor; Compound C: AMPK inhibitor. Bars represent 50 μm (a–c), 200 μm (d)
