Fig. 5
Asymmetric total synthesis of (‒)-codeine (1b) and (‒)-morphine (1a). The key steps included the Friedel-Crafts reaction, Wharton reaction, Mitsunobu reaction, and hydroamination reaction
Fig. 5 | Nature Communications
Asymmetric total synthesis of (‒)-codeine (1b) and (‒)-morphine (1a). The key steps included the Friedel-Crafts reaction, Wharton reaction, Mitsunobu reaction, and hydroamination reaction
