Fig. 3
From: Structural and functional consequences of the STAT5BN642H driver mutation
STAT5BN642H transforms T-cell subsets, resulting in differential peripheral organ infiltration. a–d Histological analysis using CD3, Ki67, and H&E staining of the skin (a), lung (b), liver (c), and brain (d) of 7- to 9-week-old wild-type (WT), human STAT5B, and human STAT5BN642H mice. Images are representative of three independent experiments. Original magnification: ×4 (left panels in c and d), ×20 and ×40 (insets), scale bars = 100 μm. e–h Flow cytometric analysis of the absolute cell numbers of CD8+, CD4+, or TCRγδ+ T-cells from the CD3+ cell population isolated from whole liver (e), brain (f), spinal cord (g), or lung (h) of 7-week old WT (n = 4) and STAT5BN642H (n = 7) mice. All data are graphed as mean ± SEM. *p < 0.05, **p < 0.01, by unpaired two-tailed Student’s t-test. Source data are provided as a Source Data file
