Fig. 4

Sex chromosome complement influences hepatic gene expression of Ldlr^−/− gonadectomized (GDX) mice. a Total probe sets on the array were filtered to retain annotated transcript clusters with reliable signal intensity. The filtered data set was analyzed by two-way ANOVA. The number of genes whose expression was significantly changed (multiple testing corrected q value ≤ 0.01) by the main effects of gene status (XX vs XY), biological sex (male vs. female), as well as by interaction, are listed. Note that only genes significant by the chromosome effect survived multiple testing correction. b Fold change in gene expression (log 2 scale, x-axis) and statistical significance (p value, y-axis) for the main effect of chromosome are plotted. Genes labelled in blue exhibited significant increases in livers from XY compared to XX mice; genes labelled in red exhibited significant increases in livers from XX compared to XY mice. (FXX, n = 5; FXY, n = 5; MXX, n = 4; MXY, n = 5). Source data are available as a Source Data file