Fig. 3 | Nature Communications

Fig. 3

From: Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Fig. 3

Structure refinement from NMR and EM data. a Zoom onto selected parts of the TET2 structure along the different steps of the structure determination process. The 3D EM map used at 8 Å resolution (steps 1 and 2) and 4.1 Å resolution (step 3) is shown as a gray surface. The structures shown correspond to the lowest-energy models generated by CYANA (steps 1 and 2) or XPLOR-NIH (step 3). A comprehensive view of the evolution of all structure elements is provided in Supplementary Fig. 11. b Residue-wise heavy-atom backbone RMSD relative to the crystal structure throughout different steps of the structure determination protocol

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