Fig. 5
From: Neuronal cell-subtype specificity of neural synchronization in mouse primary visual cortex
SST subtypes may play different functional roles. a–f Visual responses of example Pyr (a, b), SST Subtype I (c, d) and II (e, f) neurons. a Left: Vm traces of a Cux2 Pyr neuron in response to its preferred drifting grating stimuli (eight repetitions). Time 0 marked the stimulus onset. Right: Average spike shape with FWHM value. Note that visual stimuli brought Vm to the Up state. Due to the spontaneous Up-Down Vm oscillation, the magnitude of Vm deflections depended on the pre-stim Vrest. b Spiking (top row) and Vm (bottom row) responses of the Cux2 cell shown in a. Left and Middle columns: orientation tuning curves of spiking (top) and Vm (bottom) responses at the preferred spatial frequency (SF). Right column: Peri-stimulus time histogram (PSTH) of spiking responses to the preferred grating stimuli (top) and grand average of Vm responses (bottom). Note that Vm response was more broadly tuned than spiking response. c, d Visual responses of an SST Subtype I INs. Note the unimodally distributed Vm. Subtype I usually had low responsiveness to visual stimuli but could be highly spontaneously active. e, f Visual responses of an SST Subtype II INs. Note the bimodally distributed Vm and higher visual responses compared to Subtype I. g Properties of visually evoked Vm deflections confirmed the classification of SST subtypes by Vm dynamics and Vm-ECoG coupling. Visually evoked Vm deflection magnitude (Vis Vm Res) was plotted against Vm Skewness ξM. Subtype I and II SST INs were separated as expected. h No apparent dependence of Vm deflection magnitude on Vrest. **p < 0.01, n.s.: not significant. Error bar: s.e.m.
