Fig. 8 | Nature Communications

Fig. 8

From: Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Fig. 8

Schematic overview of PSPH upregulation in T-ALL. T-ALL cells display increased PSPH expression, which is mediated by transcriptional and translational upregulation in cells with the RPL10 R98S mutation. Overexpression of PSPH promotes serine/glycine production that supports the survival of neighboring cells. Moreover, serine catabolism fuels formate production and subsequent purine synthesis that enhances proliferation of the leukemic cell itself

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