Fig. 1
Sepsis patients present with elevated inflammasome markers. a–c Plasma concentration of CRP, PCT a, IL-6, IL-8 b, IL-1β, IL-18, and HMGB1 c in healthy controls, abdominal surgery patients within the first 24 h after surgery and intra-abdominal origin septic patients within the first 24 h of admission to the surgical critical unit; dotted lines in a represent standard threshold for CRP and PCT in healthy population. d Percentage of monocytes from healthy controls and septic patient positives for active caspase-1 labeled with FLICA (left) or positives for intracellular ASC specks (right). e Fold increase of circulating ASC specks in the plasma of surgery controls and septic patients compared with healthy controls. Each dot represents an individual patient; average ± standard error is represented in all panels; exact n number for each panel is presented in Source Data file; *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significant difference (p > 0.05); Mann–Whitney test for a; Kruskal–Wallis test for b–e
