Table 1 Gene function prediction accuracy

From: Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis

Database

Number of gene sets

Gene sets ≥ 10 genes

Gene sets with significant predictive power

Median AUC

Reactome

2,143

1,388

1,150

0.87

GO molecular function

4,070

726

398

0.82

GO biological process

11,753

2,576

1,115

0.82

GO cellular component

1,609

500

370

0.84

KEGG

186

186

168

0.84

HPO

7,920

3,281

1,887

0.73

  1. Note: Gene co-expression information of 31,499 samples is used to predict gene functions. We show the prediction accuracy for gene sets from different databases
  2. AUC area under the curve, GO gene ontology, HPO human phenotype ontology
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