Fig. 1
From: IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Submucosal mast cell numbers are increased in gastric cancer in mice and humans. a Representative cross sections of stomachs of 100 day old gp130 mutant mice of the indicated genotype and stained with toluidine blue showing the affected antrum (AN) and antral tumor (AT), respectively. Mast cells appear purple (arrows). Scale bars = 50 µm. b Quantification of submucosal mast cell in sections depicted in (a). n = 7 mice per cohort obtained from two independent experiments, one-way ANOVA F (DFn = degree of freedom nominator, Dfd = degree of freedom denominator) = 34.96 (3, 24). c Representative sections of toluidine blue-stained biopsy cores of human gastric cancer (GC) and adjacent submucosa and of normal stomach submucosa. Scale bars = 50 µm. d Quantification of submucosal mast cell in sections depicted in c. Each symbol represents an individual patient biopsy from submucosa of normal (N; n = 22), gastritis (Gas; n = 2), intestinal metaplasia (IM; n = 4), diffuse (Dif; n = 8), mixed (Mix; n = 3), and intestinal-type (Int; n = 8) gastric cancer. One-way ANOVA F (DFn, Dfd) = 5.809 (5, 41). Data are represented as mean ± SEM, with p < 0.05 considered significant. Source data are provided as a Source Data file. See also related Supplementary Fig. 1
