Fig. 4 | Nature Communications

Fig. 4

From: Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

Fig. 4

Dlx-cKO mice have an upregulation of NMDA receptors at the postsynaptic membrane. a Representative western blot results for several major ionotropic glutamate receptor subunits from postsynaptic density membrane fractions. Samples are from pairs of WT and Dlx-cKO littermates. b–f Dlx-cKO mice show a selective increase in levels of GluN1 and GluN2B, two of the major subunits that compose the NMDA receptor (WT, n = 10 mice; Dlx-cKO, n = 10 mice; unpaired t-test or Mann–Whitney test). Full-scan western blots of all samples are available in Supplemental Fig. 6. *p < 0.05. Source data are provided as a Source Data file

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