Fig. 6
R59X mice have an upregulation of NMDA receptors at the postsynaptic membrane. a Schematic of the R59X nonsense mutation at arginine 59, which results in early truncation of the catalytic domain of CDKL5. b Representative western blot results for several major ionotropic glutamate receptor subunits from postsynaptic density membrane fractions. Samples are from pairs of WT and R59X littermates. c–g R59X mice show a selective increase in level of GluN2B, a major subunit of the NMDA receptor (WT, n = 8 mice; R59X, n = 8 mice; unpaired t-test or Mann–Whitney test). Full-scan western blots of all samples are available in Supplemental Fig. 6. Source data are provided as a Source Data file
