Fig. 3
Recorded and modelled action potentials from atrial and sinus node myocytes. a Atrial action potentials generated by a biophysically detailed model of a mouse atrial myocyte. Inset shows action potentials recorded from mouse atrial muscle with a microelectrode. b Action potentials generated by the model when ionic currents were adjusted according to the relative abundance of the corresponding ion channels in the sinus node. The action potential is transformed into a sinus node-like action potential. Inset shows action potentials recorded from mouse sinus node with a microelectrode. MS: mass spectrometry; Vm: membrane voltage
