Fig. 6
From: Crystal structure of an adenovirus virus-associated RNA
Structural similarities with the tRNA ASL and codon–anticodon interactions. a Secondary structures of VA-I S7-L8 region and a tRNAGly ASL. Their base-pairing partners, VA-I L10, mRNA codon, and rRNA are in gray. Numbering of tRNA, mRNA, and rRNA are preceded by “t”, “m”, and “r”, respectively. b Overlay of the tertiary structures. Overall RMSD is 2.2 Å. c Structural configuration of the codon–anticodon interactions in the P-site of the ribosome (PDB: 4V5D[https://www.rcsb.org/structure/4v5d])45,46. The tRNA, mRNA, rRNA are shown in green, yellow, and blue, respectively. d A nearly identical structural configuration was observed in T-box riboswitch-tRNA co-crystal structures (PDB: 4LCK[https://www.rcsb.org/structure/4lck])47,48. Note the cross-strand stacking by conserved purines (tRNA t37 and T-box A90). e Codon–anticodon-like interactions in the VA-I RNA central domain. The 3-bp duplex is presumably stabilized by stacking by G106, which occupies a position equivalent to tRNA purine t37
