Fig. 4
From: Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
Synthesis and screening of the OBOC library. a Synthesis of 1-based OBOC library comprising 2401 bead-linked peptides. Reagents and conditions: a 20% piperidine/NMP, b HATU, HOAt, i-Pr2NEt, NMP, 40 °C (rt for 9). b Schematic diagram of selection of the compounds belonging to groups A–C. A dot plot of fluorescence intensity against bead number (1–7510) in the 2-complexation assay is also displayed. Fluorescence intensity corresponds to the relative amount of 2H. Beads exhibiting a fluorescence intensity >1000 a.u. are plotted as red dots. Source data are provided as a Source Data file
