Fig. 5

Decoupling of slow and fast timescales of synaptic input. a Correlation in synaptic input to pairs of neurons (n = 66) on slow timescale (i.e. input rate modulation, abscissa) vs. fast correlation (synaptic potentials, ordinate). A departure from the unity line (orange) indicates that correlated rate modulation is not caused by the same synaptic drive. As a control, paired recordings from same cells (n = 5) do not exhibit such a departure (purple points indicated). Confidence limits assessed as 2σ from the mean of shuffled data (σ = standard deviation). Pair from Fig. 4a–e indicated (triangle). Error bars indicate standard deviation. b Synaptic correlation (fast) is scattered close to zero (with a slight positive bias) and has only 4.5% (n = 3/66) above the 95% confidence limit. c Slow correlation has a weak mode close to 1. d Close proximity of MNs (biocytin (red) and Choline Acetyl Transferase–stained (ChAT, green)) does not grant high correlation in synaptic input (R = 0.36, right green point in a). Nissl stain in blue. Location in the left ventral horn. Scale bar 50 μm. D: Dorsal, M: Medial. Each point in a represents the mean correlation of repeated measures of same sample pair with standard deviation as error bars