Fig. 8 | Nature Communications

Fig. 8

From: Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Fig. 8

Model for the antifibrotic mechanism of action of metformin in human lung fibrosis. Metformin activates AMPK signaling in myofibroblasts, leading to suppression of collagen production, and induces lipogenic differentiation via an AMPK-independent mechanism involving BMP2 release and PPARγ phosphorylation. Arising lipofibroblasts are known to support type 2 alveolar epithelial stem cells in the lung

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