Fig. 2

snDrop-seq clusters show distinct expression profiles. a Dot plot of select average gene expression values (log scale) and percentage of nuclei expressing these genes within each cluster (Fig. 1b) for known (bold) and newly discovered cell-type marker genes (see Methods, Supplementary Data 7). b Heatmap showing cluster-specific gene specificity scores (see Methods) for differentially expressed genes associated with CKD eQTL²¹ and hypertension risk loci²² (systolic and diastolic blood pressure variants are indicated). The genes corresponding to these clusters are in Supplementary Data 8. Asterisks indicate higher cluster enrichment (proportion of differentially expressed genes associated with each cluster) of CKD-associated eQTLs in POD and hypertension risk factors in MC. Source data are provided as a Source Data file. CKD chronic kidney disease, eQTL expression quantitative trait loci, POD podocytes