Fig. 1
Combined TLR/RLR/STING signaling is needed to protect mice from lethal MCMV infection. C57BL/6 (n = 15), IFNAR KO (Ifnar−/−, n = 15), MyTrMa KO (Myd88−/−Trif−/−Mavs−/−, n = 11), STING KO (Tmem173−/−, n = 9), and MyTrMaSt KO (Myd88−/−Trif−/−Mavs−/−Tmem173−/−, n = 9) mice were i.v. infected with 5 × 105 pfu MCMV Δm157 and a survival, as well as b body weight was monitored daily. Similarly, C57BL/6 (n = 15), cGAS KO (Cgas−/−, n = 6), and MyTrMaGa KO (Myd88−/−Trif−/−Mavs−/−Cgas−/−, n = 5) mice were infected and c survival and d body weight were monitored daily. Survival and body weight of cGAS KO and MyTrMaGa KO mice were analyzed in the same experiments as the mice from Fig. 1a, b. Therefore, the depicted C57BL/6 control data are the same ones as in Fig. 1a, b. In case body weight decreased by more than 20% of the initial value, or when the overall health status was dramatically impaired, mice were sacrificed. Data represent at least two independently performed experiments. Error bars indicate mean ± s.e.m. (*p ≤ 0.0247, ***p ≤ 0.0001; a Log-rank (Mantel Cox) Test was used to calculate p-values)
