Table 1 7D10-H binding affinities with and neutralization of mutant NTDs or pesudoviruses

From: Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Analyte

kD (M)

Fold decrease

IC50 (µg mL−1)

Fold decrease

WT

2.50E−08

1.00

0.057

1

Y18A

1.73E−07

6.93

0.583

10.16

D20A

2.14E−07

8.57

3.454

60.17

P23A

2.57E−07

10.29

0.368

6.42

D24A

N.D.

–

N.D.

–

V26A

3.05E−07

12.20

10.440

181.88

S28A

1.31E−07

5.24

0.221

3.86

E188A

3.70E−06

148.00

N.D.

–

S191A

5.95E−08

2.38

0.210

3.65

N222Q

2.80E−06

112.00

2.869

49.98

N226A

1.84E−07

7.35

0.765

13.32

L234A

1.67E−07

6.70

0.883

15.38

R235A

N.D.

–

N.D.

–

N236A

1.77E−07

7.08

0.062

1.08

  1. N.D. no binding or no pseudovirus neutralization observed
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