Fig. 1

Somatic mutations and copy number alterations in pulmonary LELC. a The number of somatic mutations and copy number altered genes for each pulmonary LELC samples in the discovery cohort. Gender, age, smoking status, and tumor stages are listed at the bottom according to the samples. b Signatures are displayed according to the 96-substitution classification, with x-axis showed mutation types and y-axis showed the estimated mutations of each mutation type, which are identified by a Bayesian NMF algorithm. c Frequently mutated genes in the discovery cohort and validation cohort. The two red dashed line denote three and five mutated patients, respectively. Genes mutated in more than five patients are labeled with bold font. LELC, lymphoepithelioma-like carcinoma; SCNA, somatic copy number aberration; NA, not applicable; INDEL, insertion and deletion