Fig. 5

Comparison between pulmonary LELC and other associated cancer types. a Distribution of non-silent mutation rates of pulmonary LELC and other associated cancer types. The upper numbers indicate the number of samples for each cancer type. Black lines in the boxplot denote median mutation rate for each cancer type and outliers are shown as dots. All the other cancer types are statistically tested by unpaired two-side t-test with pulmonary LELC. *P-value < 0.05 and **P-value < 0.0001. b Mutation spectrum of six mutation type for each cancer type. c Clustering of 96 subtypes based on six mutation types and nucleotides flanking the mutated base for each cancer type. d SCNA comparison of pulmonary LELC and other cancer types. e Frequency comparison of genes with copy number amplification (red) or deletion (blue) for three major oncogenic pathways: NF-kappa B, Cell cycle and Jak/STAT/PI(3)K. Percentages of samples mutated in each cancer type are shown in gray. NPC, nasopharyngeal carcinoma; LELC, lymphoepithelioma-like carcinoma; NKTCL, natural killer/T cell lymphoma; STAD, stomach adenocarcinoma; HNSC, head and neck squamous cell carcinoma; EBV, Epstein-Barr virus; HPV, human papillomavirus; LUAD, lung adenocarcinoma; SCLC, small-cell lung carcinoma; LUSC, lung squamous cell carcinoma; SCNA, somatic copy-number alterations; Mb, megabase