Fig. 2
Regional association plot for GWAS and TWMR analyses. Top panels show single-SNP association strengths (y axis shows the −log10(p value)) versus genomic position (on hg19/GRCh37 genomic build; x axis) around the most significant SNP, indicated with a purple dot. Lower panels illustrate gene causal association strengths (y axis shows the −log10(p value)) versus genomic position. Genes highlighted in gray were not tested (i.e., they do not pass the heterogeneity test or not have significant eQTLs). Green dotted lines represent GWAS and TWMR significance thresholds. Note that for educational attainment and total cholesterol the most significant SNP did not reach GW significance (top), whereas TWMR pinpoints to putative causal genes (bottom)
