Fig. 2
From: Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
GFP-PR28 homozygous mice display reduced body weight and decreased survival. a Representative image showing the body size of the control and homozygous mice at 20 days of age. b Body weight curves of control, heterozygous, and the homozygous mice from postnatal day 11 to 33. Two-way ANOVA, Bonferroni post hoc test; n = 4, 6, 6, 6 mice. c Kaplan–Meier survival curve of the control and homozygous mice. Gehan–Breslow–Wilcoxon test, n = 12, 11 mice. Control: GFP-PR28flox/flox;Thy1-Cre-, Homo: GFP-PR28flox/flox;Thy1-Cre + (c). All data are displayed as mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001
